报告题目：Cargo receptors and adaptors of protein trafficking between endomembrane compartments in plants
报告人： Inhwan Hwang 教授
工作单位：Department of Life Science, Pohang University of Science and Technology，Korea
报告时间：2014-10-7（星期二）上午9:30
报告地点：理科楼A201
Inhwan Hwang教授于1988年获得University of North Carolina-Chapel Hill，USA的博士学位，目前是韩国Pohang University of Science and Technology生命科学系的教授。他的研究方向为植物细胞内囊泡运输，细胞器发生及细胞器之间的通讯，细胞重编程，植物细胞生物反应器，以及ABA合成与信号转导。在国际一流杂志如Dev.cell，PNAS, Plant cell, Current bilogy上发表近130篇研究论文。他目前是Plant and Cell Physiology，Frontiers in Plant traffic，Frontiers in Plant Cell Biology的编委以及Journal of Plant Biology的副主编。
Cargo receptors and adaptors for protein trafficking in plant cells
Inhwan Hwang
Division of Integrative Biosciences and Biotechnology, Department ofLife Sciences, Pohang University of Science and Technology, Pohang, 790-784, Korea
Vesicle-mediated protein trafficking is an essential process for distribution of newly synthesized proteins to various endomembrane compartments. In addition, it also plays a crucial role in reorganization of protein composition of these organelles. For this process, cargo proteins are delivered by vesicles. Many different types of vesicles are used in protein trafficking depending on the types of organelles. One of them is the clathrin-coated vesicles which are mainly used in trafficking among post-Golgi compartments. For delivery of cargoes by clathrin-coated vesicle, first cargoes have to be specifically sorted by cargo receptors and then clathrin has to be recruited to the donor compartments by adaptor proteins. Therefore, the cargo receptor and adaptor proteins are essential components of clathrin-mediated proteins trafficking at the post-Golgi compartments. In plants, vacuolar sorting receptors (VSRs) are essential in vacuolar trafficking of soluble cargoes from the TGN to the prevacuolar compartments. VSRs specifically sort vacuolar cargoes at the TGN. To recruit clathrin to the donor compartments, clathrin adaptor proteins are necessary. Many different types of clathrin adaptor proteins exist in plants. One of them is adaptor protein complexes (APs) composed of four different subunits. Another group of proteins is monomeric adaptors called Epsin-related proteins. They work at both the TGN and plasma membrane to recruit clathrin for vesicle formation. They can be divided into two groups, one for vacuolar trafficking working at the TGN and the other for endocytosis working at the plasma membrane. In the talk, I will present recent findings on the mechanism of AtVSRs and two types of adaptors proteins, APs and Epsin-related proteins in vacuolar trafficking and endocytosis in plants.
